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KMID : 0605619980050020235
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Journal of Korean Society of Biological Psychiatry
1998 Volume.5 No. 2 p.235 ~ p.242
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The Relationship between Lipid Peroxidation of Red Blood Cell Membrane, and Mean Corpuscular Volume and Liver Enzyme Markers in Alcohol Dependence Patients
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1정성윤/1Seong Yun Jeong
1최인근/1서국희/2강희정/1Ihn Geun Choi/1Guk Hee Suh/2Hee Jung Kang
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Abstract
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Objectives : Alcohol-induced oxidative stress has been known to injure various tissues
or organs. This stress is related with free radicals which are produced as the result of
long-term alcohol consumption. Malonyldialdehyde(MDA) is produced by the interaction
of free radicals and cell membrane lipids, and indicates the degree of lipid peroxidation
indirectly. The purpose of this study was to investigate the relationship between red
blood cell(RBC) membrane lipid peroxidation by free radicals, and associated hepatic
injuries and hematologic changes.
Methods : Thirty-three subjects diagnosed as alcohol dependence according to
DSM-IV diagnostic criteria were evaluated within 72 hours after discontinuing alcohol
drinking. Clinical characteristics were evaluated by CAGE questionnaire and Korean
Michigan Alcoholism Screening Test(MAST). RBC membrane MDA level was measured
as the marker of RBC membrane lipid peroxidation. Aspartate aminotransferase(AST),
alanine aminotransferase(ALT) and gamma-glutamyltransferase(GGT) were used as the
biochemical markers of liver damage due to alcohol ingestion. The alcohol-induced
hematologic change was assessed by mean corpuscular volume(MCV).
Results : The results were as follows. Clinical characteristics were not different
between two groups having normal and abnormal levels of AST, ALT, GGT or MCV.
The levels of MDA were not correlated with the clinical characteristics and serum levels
of AST, ALT and GGT. However, there was a significant correlation between the levels
of MDA and the value of MCV(p=0.017).
Conclusions : These findings suggest that oxidative stress in alcohol dependence may
not be reflected in liver enzyme markers such as AST, ALT and GGT, but may be
reflected in MCV.
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